protein

COMPLEXIN1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about COMPLEXIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for Complexin1 Protein

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🔬 Protein Info

Gene Symbol	COMPLEXIN1
Function	is a small synaptic protein (134 amino acids, ~15 kDa) that critically regulates neurotransmitter release by modulating SNARE complex assembly and fusion kinetics.
Subcellular Localization	</th><td>Presynaptic terminals, synaptic vesicles</td></tr>
Molecular Weight	16 kDa
Amino Acids	136 aa
GeneCards	COMPLEXIN1
Human Protein Atlas	COMPLEXIN1
N-terminal domain (aa 1-50)	Contains the "activator" region that promotes fusion by facilitating SNARE complex zippering. This domain penetrates the SNARE bundle and accelerates the final stages of fusion [@lin2011].
Central α-helical domain (aa 51-100)	The core SNARE-interacting region that binds to assembled SNARE complexes. This domain contains two α-helices that wrap around the SNARE bundle, stabilizing the fusion-competent state [@rizo2019].
C-terminal domain (aa 101-134)	The "clamp" region that prevents spontaneous fusion by competing with synaptotagmin for SNARE binding. This domain anchors complexin to the synaptic vesicle membrane [@tang2006].
Docking	May contribute to the proper positioning of vesicles at active zones
Priming	Stabilizes the SNARE complex in a fusion-competent state
Fusion triggering	Works in concert with synaptotagmin to trigger rapid fusion upon calcium entry
Recycling	Facilitates the disassembly and recycling of SNARE components after fusion
Synchronous release	Essential for fast, action potential-evoked release through its interaction with synaptotagmin and SNARE complexes [@cho2015].
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

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Canonical Page

Complexin-1 Protein

protein · 1149 words

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Pathway Diagram

graph TD
    COMPLEXIN1["COMPLEXIN1"]
    neurodegeneration["neurodegeneration"]
    COMPLEXIN1 -->|"implicated_in"| neurodegeneration
    style COMPLEXIN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Related Research

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