gene

COQ2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about COQ2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

COQ2 encodes the para-hydroxybenzoate polyprenyltransferase, the rate-limiting enzyme in coenzyme Q (CoQ10) biosynthesis, with variants causing mitochondrial disorders and potential relevance to Parkinson's disease.

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🧬 Gene Info

Gene Symbol	COQ2
Full Name	Coenzyme Q Biosynthesis Protein COQ2
Aliases	CoQ10
Chromosome	4q22.1
Protein Type	Enzyme
Function	is a mitochondrial enzyme that catalyzes the rate-limiting step in coenzyme Q (CoQ10, ubiquinone) biosynthesis.
Molecular Weight	20 kDa
Amino Acids	421 aa
GeneCards	COQ2
Human Protein Atlas	COQ2
COQ4	Complex scaffold
COQ6	Hydroxylase
COQ7	Hydroxylase (COQ7 is also called COQ5 in some organisms)
COQ8A/COQ8B	Kinases
COQ9	Lipid-binding chaperone
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COQ2 Gene - Coenzyme Q Biosynthesis Protein COQ2

gene · 798 words

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COQ2 Protein

protein · 924 words

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Pathway Diagram

graph TD
    COQ2["COQ2"]
    neurodegeneration["neurodegeneration"]
    COQ2 -->|"implicated_in"| neurodegeneration
    style COQ2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning COQ2 in their description or question text

No additional research found