Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COX20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
COX20 (Cytochrome c Oxidase Assembly Factor 20) - essential mitochondrial protein for Complex IV assembly, associated with cerebellar ataxia and hearing loss
| Gene Symbol | COX20 |
| Full Name | Cytochrome c Oxidase Assembly Factor COX20 |
| Aliases | Cytochrome c Oxidase Assembly Factor 20, Cytochrome C Oxidase Assembly Factor |
| Chromosome | 1p31.3 |
| Function | is a nuclear-encoded mitochondrial protein that plays an indispensable role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain. |
| Primary Expression | High in cerebellum, inner ear, heart, skeletal muscle |
| Molecular Weight | 22 kDa |
| Amino Acids | 198 aa |
| UniProt ID | Q9Y4Y6 |
| NCBI Gene ID | 91574 |
| Ensembl ID | ENSG00000173391 |
| GeneCards | COX20 |
| Human Protein Atlas | COX20 |
| Transmembrane domain | Single α-helical transmembrane segment anchors COX20 in the inner mitochondrial membrane |
| Intermembrane space domain | C-terminal region faces the intermembrane space where it interacts with COX1 and other assembly factors |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
COX20["COX20"]
neurodegeneration["neurodegeneration"]
COX20 -->|"implicated_in"| neurodegeneration
style COX20 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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