Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CX3CR1-TREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.40 |
| CX3CR1 | co_associated_with | gene | 0.30 |
| TREM2 | co_associated_with | gene | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-7597968b | targets | hypothesis | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CX3CR1-TREM2 Integration for Synapse Pruning Normalization | 0.776 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Technology insight: imaging neurodegeneration in Parkinson's disease. [PMID:18382437] | Unknown | Nat Clin Pract Neurol | 2008 | 0 |
| MicroRNAs in neurodegeneration. [PMID:18662781] | Unknown | Curr Opin Neurobiol | 2008 | 0 |
| TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124] | Unknown | Prog Brain Res | 2008 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning CX3CR1-TREM2 in their description or question text
No additional research found