Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Chromatin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Enhancers | component_of | mechanism | 0.95 |
| Brain Development | involved_in | process | 0.90 |
| Brain Development | involved_in | process | 0.85 |
| Mesoderm Development | involved_in | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| JAK | modulates | protein | 0.90 |
| H3K9ac | regulates | process | 0.70 |
| JAK | regulates | protein | 0.64 |
| 31806696 | acts as | paper | 0.60 |
| DNA_DAMAGE | regulates | phenotype | 0.56 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Acteoside treatment in LPS-induced SALI mouse model | validation | sepsis-associated acute lung i | 0.900 | 0.00 | LPS-induced SALI mouse model | proposed | N/A |
| Nrf2 inhibitor ML385 mechanism validation experiment | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells and/or mouse mo | proposed | N/A |
| Acteoside effects on RAW264.7 macrophage cells | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells | proposed | N/A |
| Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | completed | $6,550,000 |
| Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti | validation | Neurodegeneration | 0.400 | 0.50 | human | completed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Sertad4 Regulates Pathological Cardiac Remodeling. [PMID:41889836] | Francois A, Bermeo-Blanco O, Nguyen BT, | bioRxiv : the preprint server | 2026 | 0 |
| Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of In [PMID:41874277] | Wang Z, Li P, Yin F, Zhang H, Wang S, Te | Journal of medicinal chemistry | 2026 | 0 |
| Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthri [PMID:41904167] | Zhao Q, Xu T, Du Z, Lu X, Zhang Y, Peng | Nature communications | 2026 | 0 |
| Molecular insights for the tumor suppressor role of SPOP in prostate cancer. [PMID:41707797] | Yan P, Xue X, Hou T, Wang J, Jiang W et | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| Nutrient-driven histone acetylation underlies energy storage and mobilization. [PMID:41786244] | Chen L, Zhu L, Xiao H, Wang X, Xia F et | Mol Metab | 2026 | 0 |
| Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 De [PMID:41852276] | Yamakoshi H, Watanabe R, Segawa R, Ishih | Journal of medicinal chemistry | 2026 | 0 |
| The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING med [PMID:41917296] | Zhao J, Luo X, Wang Z, Luo W, Wu S, Ma X | Inflammation research : offici | 2026 | 0 |
| Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin r [PMID:41807492] | Li H, Li Q, Wan T, Wang Y, Zhang S | Scientific reports | 2026 | 0 |
| Targeting BRD4-A Promising Therapeutic Option for Glioblastoma? [PMID:41828493] | Lindner M, Lisińska D, Kędzierzyńska A, | International journal of molec | 2026 | 0 |
| High-intensity interval training alleviates COPD-induced gastrocnemius muscle dy [PMID:41865095] | Zhu C, Peng W, Yang L, Zhang W | Journal of muscle research and | 2026 | 0 |
| A photothermal immune hydrogel dressing for enhanced post-melanoma resection tre [PMID:41877232] | Tan D, Zhu W, Liu S, Liao F, Xu X, Luo J | Journal of nanobiotechnology | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol [PMID:40959274] | ["Lim J", "Chae C", "Yoon J", "Cho J", " | International journal of biolo | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| A human Tau expressing zebrafish model of progressive supranuclear palsy identif [PMID:39294122] | ["Bai Q", "Shao E", "Ma D", "Jiao B", "S | Nature communications | 2024 | 0 |
| Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules. [PMID:38561350] | ["Ma B", "Khan K", "Xu T", "Xeque Amada | Journal of the American Chemic | 2024 | 0 |
| Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing. [PMID:39315698] | ["Altinbay M", "Wang J", "Chen J", "Sch\ | Nucleic acids research | 2024 | 0 |
| Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic [PMID:38643236] | ["Rosenthal Z", "Fass D", "Payne N", "Sh | Scientific reports | 2024 | 0 |
| A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune [PMID:39002520] | ["Song Z", "Li J", "He Y", "Wang X", "Ti | International immunopharmacolo | 2024 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Chromatin in their description or question text
Score: 0.610 · neurodegeneration · 2026-04-22
## Mechanistic Overview H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive Elements starts
Score: 0.566 · developmental-neurobiology · 2026-04-21
## Mechanistic Overview NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation starts from the claim that mod
Score: 0.565 · neurodegeneration · 2026-04-25
H3K9me3 Heterochromatin Loss at Pericentromeric Repeats
Score: 0.544 · neurodegeneration · 2026-04-04
## Mechanistic Overview Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling starts from the claim
Score: 0.345 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth
Score: 0.326 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth
Score: 0.000 · unknown disease · 2026-04-28
Age-related neurodegeneration stems from desynchronized epigenetic oscillators. Precisely timed, pulsed OSK expression c
Score: 0.000 · unknown disease · 2026-04-28
Different priming stimuli converge on shared chromatin remodeling cascade involving histone deacetylases and demethylase
Score: 0.000 · unknown disease · 2026-04-28
Age-related loss of synaptic plasticity results from compartmentalized chromatin dysfunction. Targeted mRNA delivery of
Score: 0.000 · unknown disease · 2026-04-28
Epigenetic modulation of tau-interacting proteins through chromatin modification Debate provenance: derived from debate
Score: 0.000 · unknown disease · 2026-04-28
Chemically-induced chromatin velocity modulators could achieve epigenetic rejuvenation without reprogramming by controll