concept

JAK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1466Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

JAK is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 853 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	JAK
Summary	Companies developing JAK inhibitors and JAK-STAT pathway modulators for Parkinson's disease neuroinflammation and neuroprotection
Related Diseases	Inflammation, Als, Cancer, Tumor, Autoimmune
Related Pathways	Nf-Κb, Jak-Stat, Mapk

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JAK["JAK"]
    JAK -->|"activates"| STAT3["STAT3"]
    JAK -->|"regulates"| GENE_EXPRESSION["GENE_EXPRESSION"]
    JAK -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    JAK -->|"target for"| Cardiovascular["Cardiovascular"]
    JAK -->|"target for"| Inflammation["Inflammation"]
    JAK -->|"target for"| Als["Als"]
    JAK -->|"target for"| Cancer["Cancer"]
    JAK -->|"target for"| Ms["Ms"]
    IL6["IL6"] -->|"activates"| JAK
    SOCS["SOCS"] -->|"inhibits"| JAK
    STAT3 -->|"activates"| JAK
    CD4["CD4"] -->|"target for"| JAK
    BCL2["BCL2"] -->|"target for"| JAK
    VIRAL_INFECTIONS["VIRAL INFECTIONS"] -->|"activates"| JAK
    STAT2["STAT2"] -->|"inhibits"| JAK
    MTOR["MTOR"] -->|"target for"| JAK

Outgoing (1012)

Target	Relation	Type	Str
Inflammation	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Nf-Κb	activates	pathway	1.00
Inflammation	regulates	disease	1.00
Als	activates	disease	1.00
Jak-Stat	activates	pathway	1.00
Inflammation	inhibits	disease	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	inhibits	disease	1.00
Mapk	activates	pathway	1.00
Jak-Stat	inhibits	pathway	1.00
Autoimmune	therapeutic_target	disease	0.95
Als	regulates	disease	0.95
Tumor	activates	disease	0.95
Tumor	inhibits	disease	0.95
Cancer	associated_with	disease	0.95
Cancer	regulates	disease	0.95
Als	treats	disease	0.95
STAT	activates	protein	0.95
Gene Expression	regulates	process	0.95
Ph-Like ALL	involved_in	disease	0.95
STAT3	activates	protein	0.90
STAT3	associated_with	gene	0.90
Chromatin	modulates	mechanism	0.90
Epigenome	modulates	mechanism	0.90
STAT3	phosphorylates	protein	0.90
JAK-STAT signaling	participates_in	pathway	0.90
NF-kB signaling	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
Apoptosis	regulates	pathway	0.90
Differentiation	regulates	pathway	0.90
Metastasis	therapeutic_target	pathway	0.90
Differentiation	therapeutic_target	pathway	0.90
Cardiovascular	therapeutic_target	disease	0.85
Neuroinflammation	activates	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Tumor	regulates	disease	0.85
Neurodegeneration	activates	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Inflammation	causes	disease	0.85
Malignant Cell Survival	associated_with	phenotype	0.85
Malignant Cell Proliferation	associated_with	phenotype	0.85
TGF-beta signaling	participates_in	pathway	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.80
MAPK signaling	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80
epigenetic regulation	participates_in	pathway	0.80

Incoming (454)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
STAT3	therapeutic_target	gene	1.00
IL-6	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ERK	activates	gene	1.00
IL-6	activates	gene	1.00
CYTOKINES	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
NF-KB	associated_with	gene	0.98
CANCER	regulates	gene	0.90
CANCER	activates	gene	0.90
INFLAMMATION	inhibits	gene	0.90
CYTOKINES	therapeutic_target	gene	0.90
NF-ΚB	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
RAS	activates	gene	0.90
IL6	activates	protein	0.87
IL-6	associated_with	gene	0.82
SOCS	inhibits	protein	0.80
Polyphenols	inhibits	compound	0.80
CANCER	associated_with	gene	0.80
CYTOKINES	activates	gene	0.80
GENES	inhibits	gene	0.80
AMPK	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
CANCER	inhibits	disease	0.80
AKT	regulates	gene	0.80
TNF	inhibits	gene	0.80
IL-6	inhibits	gene	0.80
TNF-Α	inhibits	gene	0.80
PI3K	contributes_to	gene	0.80
AKT	contributes_to	gene	0.80
GENES	activates	gene	0.80
INFLAMMATION	causes	gene	0.80
TNF-Α	activates	gene	0.80
STAT3	activates	protein	0.74
TNF	associated_with	gene	0.74
AMYLOID	associated_with	protein	0.74
ERK	therapeutic_target	gene	0.70
IL6	therapeutic_target	gene	0.70
MICRORNAS	regulates	gene	0.70
NRF2	inhibits	gene	0.70
PROINFLAMMATORY CYTOKINES	inhibits	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
VEGFA	therapeutic_target	gene	0.70
NF-ΚB	regulates	gene	0.70
BRAIN INFLAMMATION	regulates	gene	0.70
TNF	therapeutic_target	gene	0.70
NF-ΚB	contributes_to	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

JAK

Understanding Entity Pages

Summary

Wiki Pages (21)

JAK Inhibitors in Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

Astrocyte Reactivity Mechanism

Growth Factor Therapies

APOC4 — Apolipoprotein C-IV

nlrc5-protein

Neuroprotection Strategies in Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

JAK-STAT Signaling Pathway in Neurodegeneration

vegfr-signaling-neurodegeneration

IL28B (Interleukin 28B)