Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Complement Cascade / Synaptic Pruning: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA | participates_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Complement C1QA Spatial Gradient in Cortical Layers | 0.428 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross-Species Transcr [PMID:41664952] | Arif M, Hasan MN, Nozaki N, Ide Y, Akiya | Mol Carcinog | 2026 | 0 |
| The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007] | Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ, | Journal of neuroinflammation | 2024 | 0 |
| Identification of crosstalk genes and immune characteristics between Alzheimer's [PMID:39188714] | An W, Zhou J, Qiu Z, Wang P, Han X, Chen | Frontiers in immunology | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217] | Figueroa CA, Aguilera A, Chakraborty B, | Journal of the American Medica | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779] | Lee E, Kang C, Purhonen P, Hebert H, Bou | Journal of molecular biology | 2021 | 0 |
| Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. [PMID:32866962] | Zhang J, Velmeshev D, Hashimoto K, Huang | Nature | 2020 | 0 |
| Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia v [PMID:27114033] | Lui H, Zhang J, Makinson SR, Cahill MK, | Cell | 2016 | 0 |