Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Complex_I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial_respiration | catalyzes | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MT-ND1 | component_of | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CRISPR-Mediated Mitochondrial Genome Editing for Complex I D | 0.491 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Whole mitochondrial genome sequencing in individuals with Leber hereditary optic [PMID:40969215] | Srilekha S, Ambika S, Hemavathy N, Vidhy | Front Neurol | 2025 | 0 |
| Exploring rare mitochondrial DNA in Leber hereditary optic neuropathy. [PMID:41080639] | Cao S, Liu Y, Sun M, Zhang Y, Sun Y et a | Adv Ophthalmol Pract Res | 2025 | 0 |
| Respiratory Chain Complex I Deficiency in Leber Hereditary Optic Neuropathy: Ins [PMID:39578757] | Chkioua L, Amri Y, Sahli C, Nasri T, Mil | BMC Genomics | 2024 | 0 |
| Leber's hereditary optic neuropathy: Current approaches and future perspectives [PMID:34454075] | Mohana Devi S, Abishek Kumar B, Mahalaxm | Mitochondrion | 2021 | 0 |
| Mitochondrial DNA-Associated Leigh Syndrome Spectrum. [PMID:20301352] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 | |
| Leber Hereditary Optic Neuropathy. [PMID:20301353] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 | |
| Primary Mitochondrial Disorders Overview. [PMID:20301403] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 |