Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about D2 autoreceptor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Gi/o Signaling | activates | pathway | 0.85 |
| cAMP Signaling | regulates | pathway | 0.85 |
| Gi/o signaling | regulates | pathway | 0.70 |
| RGS6 | regulated_by | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RGS6 | associated_with | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pharmacologic modulation of D2 autoreceptor-Gi/o signaling i | 0.420 | neurodegeneration | Does RGS6 upregulation or D2 autorecepto |
| D2 Autoreceptor Partial Agonism as Compensatory Therapy for | 0.348 | neurodegeneration | Does RGS6 upregulation or D2 autorecepto |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.559
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning D2 autoreceptor in their description or question text
No additional research found