gene

RGS6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

50Outgoing

10Incoming

Summary

Page for RGS6 Gene

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🧬 Gene Info

Gene Symbol	RGS6
Chromosome	14q24.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cerebellum, Hippocampus, Retina
Molecular Weight	56 kDa
Pathways	oxidative stress response
UniProt ID	Q9Y5Z4
NCBI Gene ID	9628
Ensembl ID	ENSG00000111664
OMIM	603894
GeneCards	RGS6
Human Protein Atlas	RGS6
Symbol [@rgs2017] RGS6 [@rgs2016] [@rgs2018a] Full Name	Regulator of G Protein Signaling 6
Associated Diseases	Parkinson's disease, neurodegeneration
Known Drugs/Compounds	levodopa
Interactions	PARKINSON, AND, Α-Synuclein, NEURON
KG Connections	75 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RGS6 — AlphaFold Q9Y5Z4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RGS6["<b>RGS6</b>"]
    Neurodegeneration{"Neurodegeneration"}
    RGS6 -->|"regulates"| Neurodegeneration
    Parkinson{"Parkinson"}
    RGS6 -->|"expressed in"| Parkinson
    Camp_Signaling(["Camp Signaling"])
    RGS6 -->|"inhibits"| Camp_Signaling
    PARKINSON["PARKINSON"]
    RGS6 -->|"expressed in"| PARKINSON
    NEURODEGENERATION["NEURODEGENERATION"]
    RGS6 -->|"regulates"| NEURODEGENERATION
    Substantia_Nigra["Substantia Nigra"]
    RGS6 -->|"expressed in"| Substantia_Nigra
    Neuron["Neuron"]
    RGS6 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    RGS6 -->|"implicated in"| neurodegeneration
    NEURON["NEURON"]
    NEURON -->|"inhibits"| RGS6
    AND["AND"]
    AND -->|"inhibits"| RGS6
    style RGS6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
Gi/o Signaling	inhibits	pathway	0.95
Substantia Nigra Pars Compacta	expressed_in	cell_type	0.95
Gi/O Signaling	inhibits	pathway	0.95
dopamine neuron degeneration	protects_against	process	0.95
Parkinson'S Disease	protects_against	disease	0.95
D2 AUTORECEPTOR	associated_with	receptor	0.90
α-synuclein Accumulation	protects_against	phenotype	0.90
dopaminergic neurodegeneration	causes	process	0.90
α-synuclein accumulation	causes	process	0.90
D2 Autoreceptor Signaling	suppresses	pathway	0.90
Substantia Nigra Pars Compacta Dopamine Neurons	expressed_in	cell_type	0.90
cAMP signaling	upregulates	pathway	0.90
DRD2	modulates	gene	0.90
Dopamine Neuron Survival	protects_against	process	0.88
Dopaminergic Neurodegeneration	protects_against	process	0.85
Camp	regulates	compound	0.85
SNCA	downregulates	gene	0.85
nigrostriatal dopamine	mediates	phenotype	0.85
motor deficits	suppresses	phenotype	0.85
Neurodegeneration	regulates	disease	0.65
Parkinson	expressed_in	disease	0.65
neurodegeneration	associated_with	disease	0.60
neurodegeneration	regulates	disease	0.60
striatum	expressed_in	brain_region	0.60
Camp Signaling	inhibits	pathway	0.60
PARKINSON	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
Neuron	inhibits	cell_type	0.60
AND	inhibits	gene	0.60
Α-Synuclein	inhibits	protein	0.60
neurons	expressed_in	cell_type	0.60
Parkinson's disease	expressed_in	disease	0.60
Parkinson's disease	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Parkinson's disease	regulates	disease	0.60
Substantia Nigra	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
DOPAMINERGIC	associated_with	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
DOPAMINE	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
Neuron	activates	cell_type	0.50
NEURONS	activates	concept	0.50
SYNUCLEIN	activates	concept	0.50
DOPAMINE	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
SYNUCLEIN	inhibits	concept	0.50
DOPAMINE	inhibits	concept	0.50
α-SYNUCLEIN	inhibits	concept	0.50

Incoming (10)

Source	Relation	Type	Str
levodopa	targets	drug	0.60
NEURON	inhibits	gene	0.60
NEURODEGENERATION	associated_with	entity	0.60
LATE	inhibits	entity	0.60
NEURODEGENERATION	regulates	entity	0.60
PARKINSON	expressed_in	gene	0.60
AND	inhibits	gene	0.60
late	inhibits	disease	0.50
Neurodegeneration	associated_with	disease	0.50
Neurodegeneration	regulates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RGS6

Understanding Entity Pages

Summary

Wiki Pages (11)

RGS6 Gene

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RGS6 Protein

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