Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dab2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DAB2 |
| Full Name | Disabled 2, Clathrin Adaptor Protein |
| Chromosome | 5p13.2 |
| Protein Type | Adaptor Protein |
| Function | encodes a clathrin-associated adaptor protein that plays critical roles in endocytosis, signal transduction, and protein homeostasis. |
| Amino Acids | 830 aa |
| Exons | 22 |
| Pathways | Notch |
| UniProt ID | [P98073](https://www.uniprot.org/uniprot/P98073) |
| Ensembl ID | ENSG00000153046 |
| GeneCards | DAB2 |
| Human Protein Atlas | DAB2 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
DAB2["DAB2"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
AGGF1["AGGF1"] -->|"upregulates"| DAB2["DAB2"]
Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
AGGF1["AGGF1"] -->|"activates"| VEGFA["VEGFA"]
AGGF1["AGGF1"] -->|"upregulates"| FLT4["FLT4"]
AGGF1["AGGF1"] -->|"upregulates"| EPHB4["EPHB4"]
style DAB2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
style AGGF1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
style VEGFA fill:#4a1a6b,stroke:#333,color:#e0e0e0
style FLT4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style EPHB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:DAB2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGGF1 | upregulates | gene | 0.80 |
| benchmark_ot_ad_answer_key:DAB2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||