gene

dab2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dab2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections
0Hypotheses
0Analyses
1Outgoing
2Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolDAB2
Full NameDisabled 2, Clathrin Adaptor Protein
Chromosome5p13.2
Protein TypeAdaptor Protein
Functionencodes a clathrin-associated adaptor protein that plays critical roles in endocytosis, signal transduction, and protein homeostasis.
Amino Acids830 aa
Exons22
PathwaysNotch
UniProt ID[P98073](https://www.uniprot.org/uniprot/P98073)
Ensembl IDENSG00000153046
GeneCardsDAB2
Human Protein AtlasDAB2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

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SORL1 Protein

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VLDL Receptor

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LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

gene · 1463 words

Pathway Diagram

flowchart TD
    DAB2["DAB2"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    AGGF1["AGGF1"] -->|"upregulates"| DAB2["DAB2"]
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
    Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    AGGF1["AGGF1"] -->|"activates"| VEGFA["VEGFA"]
    AGGF1["AGGF1"] -->|"upregulates"| FLT4["FLT4"]
    AGGF1["AGGF1"] -->|"upregulates"| EPHB4["EPHB4"]
    style DAB2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
    style AGGF1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
    style VEGFA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FLT4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EPHB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (1)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:DAB2data_indataset_row0.00

Incoming (2)

SourceRelationTypeStr
AGGF1upregulatesgene0.80
benchmark_ot_ad_answer_key:DAB2data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found