gene

DDX46

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX46: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for DDX46 — DEAD-Box Helicase 46

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	DDX46
Full Name	DEAD-Box Helicase 46
Chromosome	5q31.2
Function	is a member of the DEAD-box family of RNA helicases that functions as an essential component of the U2 small nuclear ribonucleoprotein (snRNP) complex.
Primary Expression	both neuronal and glial cell populations, with particularly high expression in excitatory neurons [1](https://human
Molecular Weight	80 kDa
Amino Acids	726 aa
Exons	23
UniProt ID	[Q7Z417](https://www.uniprot.org/uniprot/Q7Z417)
Ensembl ID	ENSG00000146083
OMIM	614351
GeneCards	DDX46
Human Protein Atlas	DDX46
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDX46 — DEAD-Box Helicase 46

gene · 1120 words

→

DDX46 Protein

protein · 961 words

→

Pathway Diagram

graph TD
    DDX46["DDX46"] -->|"DEAD-box"| Helicase["RNA Helicase"]
    DDX46 -->|"Component of"| U2snRNP["U2 snRNP"]
    U2snRNP -->|"Essential for"| Spliceosome["Spliceosome Assembly"]
    Spliceosome -->|"Catalyzes"| Splicing["Pre-mRNA Splicing"]
    DDX46 -->|"Unwinds"| RNADuplexes["RNA Duplexes"]
    DDX46 -->|"Regulates"| BranchPoint["Branch Point Recognition"]
    DDX46 -->|"Requires"| ATP["ATP Hydrolysis"]
    DDX46 -.->|"Mutations affect"| HSC["Hematopoiesis, Development"]

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDX46 in their description or question text

No additional research found