Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DFFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DFFA |
| Full Name | DFFA |
| Chromosome | 1p36.22 |
| Protein Type | Gene |
| Function | The DFFA gene encodes DFF45 (DNA Fragmentation Factor 45 kDa), also known as ICAD (Inhibitor of Caspase-Activated DNase). |
| Molecular Weight | 45 kDa |
| Amino Acids | 331 aa |
| UniProt ID | O00273 |
| NCBI Gene ID | 1676 |
| Ensembl ID | ENSG00000164111 |
| GeneCards | DFFA |
| Human Protein Atlas | DFFA |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DFFA["DFFA"]
neurodegeneration["neurodegeneration"]
DFFA -->|"implicated_in"| neurodegeneration
style DFFA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||