gene 1,992 words KG: CIDEA 2026-03-25
kind:genesection:genesstate:publishedtopic:alzheimers
Contents

CIDEA — Cell Death-Inducing DFFA-Like Effector A

🧬 Gene Info
Gene SymbolCIDEA
Full NameCell Death-Inducing DFFA-Like Effector A
Chromosome18p11.21
Functionis a member of the CIDE (Cell Death-Inducing DFFA-like Effector) family of proteins that play important roles in regulating cell death, lipid metabolism, and energy homeostasis.
Primary Expressionbrown adipose tissue, where it promotes lipid droplet formation and regulates thermogenesis
Subcellular LocalizationCIDEA is primarily localized to lipid droplets, which are dynamic organelles storing neutral lipids including triglyceri
Amino Acids175 aa
GeneCardsCIDEA
Human Protein AtlasCIDEA
TissueExpression Level
Brown adipose tissueHighest
LiverHigh
BrainLow-Moderate
HeartModerate
KidneyLow
Associated DiseasesAlzheimer's disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT
clinical · Pages share 5 hypotheses
A Phase 2 Double-Blind, Randomized, Placebo-Controlled
clinical · Pages share 5 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 5 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 5 hypotheses