gene

DHX36

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DHX36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for DHX36 — DEAH-Box Helicase 36

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🧬 Gene Info

Gene Symbol	DHX36
Full Name	DEAH-Box Helicase 36
Function	is a member of the DEAH-box family of RNA helicases that recognizes and resolves G-quadruplex (G4) structures in both DNA and RNA.
Molecular Weight	114 kDa
Ensembl ID	ENSG00000147050
GeneCards	DHX36
Human Protein Atlas	DHX36
DEAH motif	The characteristic DEAH-box helicase core contains nine conserved motifs (Motifs I-VI, Ia, Ib, and Q motif) essential for ATP binding and hydrolysis[@bourbigot2020]
RecA-like domains	Two RecA-like domains form the helicase motor that couples ATP hydrolysis to nucleic acid unwinding
C-terminal domain	A specialized domain required for G-quadruplex recognition
Promoter G4 resolution	Resolves G4 structures in gene promoters to facilitate transcription initiation
Transcriptional elongation	Affects RNA polymerase II processivity through G4 clearance
Chromatin association	Associates with chromatin at G-rich regulatory elements
Translation initiation	Regulates 5' UTR G4-mediated translation control
Ribosome recruitment	Facilitates ribosomal scanning through structured 5' regions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DHX36 — DEAH-Box Helicase 36

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Genes

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Pathway Diagram

graph TD
    DHX36["DHX36"]
    neurodegeneration["neurodegeneration"]
    DHX36 -->|"implicated_in"| neurodegeneration
    style DHX36 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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