Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DLX6 |
| Full Name | Distal-Less Homeobox 6 |
| Chromosome | 7q21.3 |
| Protein Type | Transcription Factor |
| Function | is a member of the DLX family of homeobox transcription factors that play critical roles in embryonic brain development, particularly in the formation of GABAergic neurons in the forebrain. |
| Primary Expression | the olfactory bulb, linking it to olfactory dysfunction common in neurodegenerative diseases: |
| Amino Acids | 326 aa |
| UniProt ID | [O43516](https://www.uniprot.org/uniprot/O43516) |
| Ensembl ID | ENSG00000106483 |
| GeneCards | DLX6 |
| Human Protein Atlas | DLX6 |
| Homeodomain binding sites | TAAT motif recognition for DNA binding |
| Enhancer elements | Remote enhancers controlling spatiotemporal expression |
| Conserved non-coding sequences | DLX5/6 ultraconserved elements with regulatory function |
| Embyronic day 10.5-18.5 | High expression in ventral telencephalon |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLX6["DLX6"]
neurodegeneration["neurodegeneration"]
DLX6 -->|"implicated_in"| neurodegeneration
style DLX6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DLX6 in their description or question text
No additional research found