protein

DNAJC14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	DNAJC14
Chromosome	12q13.12
Protein Type	Chaperone
Function	DNAJC14 is a DnaJ protein involved in ER-associated degradation (ERAD) and protein quality control.
Molecular Weight	55.8 kDa
Amino Acids	513 aa
Exons	11
GeneCards	DNAJC14
Human Protein Atlas	DNAJC14
Protein Aggregation Disorders	By participating in ERAD, DNAJC14 helps prevent the accumulation of aggregation-prone proteins that characterize many neurodegenerative conditions.
Hsp70 recruitment	The J-domain recruits and activates Hsp70 proteins
ATPase stimulation	DNAJC14 stimulates Hsp70 ATP hydrolysis
Substrate transfer	Facilitates transfer of misfolded proteins to Hsp70
conformational coupling	Couples ATP hydrolysis to substrate binding
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC14["DNAJC14"]
    neurodegeneration["neurodegeneration"]
    DNAJC14 -->|"implicated_in"| neurodegeneration
    style DNAJC14 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found