Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DnaJ Heat Shock Protein Family Member C18 |
| Aliases | DNAJC18 |
| Chromosome | 4q22.1 |
| Protein Type | Chaperone |
| Function | is a member of the DnaJ/Hsp40 family of molecular chaperones. |
| Subcellular Localization | mitochondria and assist in protein import and quality control. Further research is needed to determine if DNAJC18 has si |
| Amino Acids | 70 aa |
| Gene Type | Protein coding |
| UniProt ID | Q9H7E4 |
| NCBI Gene ID | 54962 |
| OMIM | 610091 |
| Protein Folding Assistance | Like other DnaJ proteins, DNAJC18 works in conjunction with Hsp70 family chaperones to facilitate proper protein folding |
| Protein Quality Control | Helps recognize and target misfolded proteins for degradation via the proteasome |
| Stress Response | Upregulated under cellular stress conditions including heat shock and oxidative stress |
| Transmembrane Protein Processing | Some DnaJ proteins specialize in processing polytopic membrane proteins, a function that may extend to DNAJC18 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC18["DNAJC18"]
neurodegeneration["neurodegeneration"]
DNAJC18 -->|"implicated_in"| neurodegeneration
style DNAJC18 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC18 in their description or question text
No additional research found