gene

DNAQC6

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DNAQC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DNAJC6 Gene

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🧬 Gene Info

Gene Symbol	DNAQC6
Full Name	DNAJ Heat Shock Protein Family (Hsp40) Member C6
Chromosome	1p31.3
Protein Type	Chaperone
Function	The process of synaptic vesicle recycling is essential for maintaining neurotransmitter release during sustained neuronal activity, as each vesicle fusion event requires the retrieval and reuse of syn
Molecular Weight	104 kDa
Amino Acids	935 aa
Exons	15
UniProt ID	[O75037](https://www.uniprot.org/uniprot/O75037)
Ensembl ID	ENSG00000138231
GeneCards	DNAQC6
Human Protein Atlas	DNAQC6
Client-Binding Region (aa 200-500)	This region contains multiple glycine-phenylalanine (GF)-rich sequences that facilitate binding to a broad range of client proteins, including components of the clathrin coat machinery.
Clathrin-Binding Domain (aa 600-700)	The C-terminal region contains multiple clathrin box motifs (LLDLF) that enable direct binding to the clathrin triskelion, essential for the protein's role in clathrin uncoating[^7].
Phosphorylation Sites	Multiple serine/threonine phosphorylation sites regulate the protein's activity throughout the cell cycle and during synaptic activity.
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNAJC6 Gene

gene · 1970 words

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Pathway Diagram

graph TD
    DNAQC6["DNAQC6"]
    neurodegeneration["neurodegeneration"]
    DNAQC6 -->|"implicated_in"| neurodegeneration
    style DNAQC6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning DNAQC6 in their description or question text

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