protein

DOCK1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOCK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DOCK1 (Dedicator of Cytokinesis 1) is a large guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases through its DHR-2 (Docker Homology Region 2) domain[@cote2005].

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🔬 Protein Info

Gene Symbol	DOCK1PROTEIN
Full Name	Dedicator of Cytokinesis 1 Protein
Protein Family	DOCK family (DOCK-A subfamily)
Function	is a large guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases through its DHR-2 (Docker Homology Region 2) domain[@cote2005].
Primary Expression	pyramidal and interneurons
Subcellular Localization	- DHR-2 Domain (400-750): Catalytic GEF domain that activates Rac GTPases -
Molecular Weight	215 kDa (1,864 amino acids)
Amino Acids	864 aa
UniProt ID	Q8IU85
GeneCards	DOCK1PROTEIN
Human Protein Atlas	DOCK1PROTEIN
DHR-1 Domain (1-400)	Phosphoinositide-binding region for membrane localization
DHR-2 Domain (400-750)	Catalytic GEF domain that activates Rac GTPases
SH3 Domains	Proline-rich regions for protein-protein interactions
C-terminal Region (750-1864)	Regulatory and scaffolding functions
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DOCK1PROTEIN — AlphaFold Q8IU85 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dedicator of Cytokinesis 1 Protein

protein · 966 words

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Pathway Diagram

graph TD
    DOCK1PROTEIN["DOCK1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    DOCK1PROTEIN -->|"implicated_in"| neurodegeneration
    style DOCK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning DOCK1PROTEIN in their description or question text

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