Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DUOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DUOX1 |
| Full Name | Dual Oxidase 1 |
| Chromosome | 15q21.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues including the thyroid, lung, and gastrointestinal tract, where it plays critical roles in hydrogen peroxide production, host defense |
| Molecular Weight | 175 kDa |
| Amino Acids | 545 aa |
| UniProt ID | [Q9UHD8](https://www.uniprot.org/uniprot/Q9UHD8) |
| Ensembl ID | ENSG00000155505 |
| OMIM | 607709 |
| GeneCards | DUOX1 |
| Human Protein Atlas | DUOX1 |
| Peroxidase activity | Unlike other NOX enzymes, DUOX has intrinsic peroxidase activity |
| Calcium dependence | Directly activated by calcium binding to EF-hand domains |
| Maturation factor requirement | Requires DUOXA1 for proper folding, trafficking, and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DUOX1["DUOX1"]
neurodegeneration["neurodegeneration"]
DUOX1 -->|"implicated_in"| neurodegeneration
style DUOX1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity