gene

EBI3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EBI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

Summary

EBI3 gene - Parkinson's disease risk gene encoding IL-27/IL-35 receptor subunit

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🧬 Gene Info

Gene Symbol	EBI3
Full Name	Epstein-Barr Virus Induced 3
Aliases	EBI3 gene
Chromosome	19p13.3
Protein Type	Receptor
Function	Suppresses effector T cell responses
Primary Expression	Immune cells (dendritic cells, B cells, macrophages); low in brain
Amino Acids	229 aa
Exons	6
UniProt ID	Q14213
NCBI Gene ID	10193
GeneCards	EBI3
Human Protein Atlas	EBI3
Protein	Epstein-Barr virus-induced gene 3 protein
Protein Size	229 amino acids
Associated Diseases	Parkinson's Disease, Autoimmune diseases, Multiple sclerosis
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EBI3 — AlphaFold Q14213 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["EBI3"]
    N1["IL35"]
    N0 -->|"component of"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (1)

Target	Relation	Type	Str
IL35	component_of	protein	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EBI3

Understanding Entity Pages

Summary

Wiki Pages (5)

EBI3 Gene

IL27 — Interleukin 27

IL30 — Interleukin 30 (p28 Subunit)