IL35

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Gene profile: IL35 - immunomodulatory cytokine composed of IL12A and IL27RB subunits, involved in regulatory T cell function, immunosuppression, and neuroinflammation in Alzheimer's and Parkinson's disease.

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graph TD
    IL35["<b>IL35</b>"]
    HBV_related_HCC{"HBV-related HCC"}
    IL35 -->|"modulates"| HBV_related_HCC
    Th17_cells["Th17 cells"]
    IL35 -->|"inhibits"| Th17_cells
    IL6["IL6"]
    IL35 -->|"regulates"| IL6
    STAT3["STAT3"]
    IL35 -->|"regulates"| STAT3
    NETs["NETs"]
    IL35 -->|"inhibits"| NETs
    Th17_Treg_balance["Th17/Treg balance"]
    IL35 -->|"regulates"| Th17_Treg_balance
    gp130_STAT3_ferroptosis(["gp130/STAT3/ferroptosis"])
    IL35 -->|"regulates"| gp130_STAT3_ferroptosis
    autoimmune_diseases{"autoimmune diseases"}
    IL35 -->|"associated with"| autoimmune_diseases
    cancer{"cancer"}
    IL35 -->|"associated with"| cancer
    neurodegeneration["neurodegeneration"]
    IL35 -->|"implicated in"| neurodegeneration
    IL12["IL12"]
    IL12 -->|"component of"| IL35
    EBI3["EBI3"]
    EBI3 -->|"component of"| IL35
    style IL35 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0