Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF2B3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | EIF2B3 |
| Function | EIF2B3 encodes the gamma subunit of eukaryotic translation initiation factor 2B (eIF2B), which serves as the essential guanine nucleotide exchange factor (GEF) for eIF2. |
| Molecular Weight | 50 kDa |
| Ensembl ID | ENSG00000111671 |
| GeneCards | EIF2B3 |
| Human Protein Atlas | EIF2B3 |
| Associated Diseases | Parkinson disease, vanishing white matter disease |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EIF2B3["<b>EIF2B3</b>"]
vanishing_white_matter_disease{"vanishing white matter disease"}
EIF2B3 -->|"causes"| vanishing_white_matter_disease
PKC["PKC"]
EIF2B3 -->|"participates in"| PKC
Parkinson_disease{"Parkinson disease"}
EIF2B3 -->|"associated with"| Parkinson_disease
cell_migration["cell migration"]
EIF2B3 -->|"participates in"| cell_migration
cell_proliferation["cell proliferation"]
EIF2B3 -->|"participates in"| cell_proliferation
neurodegeneration["neurodegeneration"]
EIF2B3 -->|"implicated in"| neurodegeneration
style EIF2B3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| vanishing white matter disease | causes | disease | 0.90 |
| PKC | participates_in | protein | 0.80 |
| Parkinson disease | associated_with | disease | 0.70 |
| cell migration | participates_in | biological_process | 0.70 |
| cell proliferation | participates_in | biological_process | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||