gene

PKC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

529Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

PKC is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 267 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PKC
Full Name	Protein Kinase C Alpha
Chromosome	17q24.2
Protein Family	PKC (Protein Kinase C) family
Amino Acids	672 aa
Exons	17
Pathways	Akt, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID	[P17252](https://www.uniprot.org/uniprot/P17252)
Ensembl ID	ENSG00000154229
OMIM	176960
GeneCards	PKC
Human Protein Atlas	PKC
Associated Diseases	Als, Alzheimer, Ataxia, Diabetes, Ms
Known Drugs/Compounds	metformin
Interactions	AGING, AKT, ALOX5, AMPK, Amyloid, AMYLOID
KG Connections	529 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PKC["PKC
(Protein Kinase C)"]
    
    JUN["JUN
(Transcription Factor)"]
    MTORC2["mTORC2
(mTOR Complex 2)"]
    
    NRF2["NRF2
(Antioxidant Response)"]
    KEAP1["KEAP1
(NRF2 Regulator)"]
    
    TNF["TNF
(Tumor Necrosis Factor)"]
    Inflammation["Inflammation
(Neuroinflammation)"]
    
    AKT["AKT Pathway
(Cell Survival)"]
    MAPK["MAPK Pathway
(Cell Signaling)"]
    PI3K["PI3K Pathway
(Growth Signaling)"]
    
    Apoptosis["Apoptosis
(Cell Death)"]
    
    ALS["ALS
(Amyotrophic Lateral
Sclerosis)"]
    MS["Multiple Sclerosis
(Demyelinating Disease)"]
    Ataxia["Ataxia
(Movement Disorder)"]
    Neurodegeneration["Neurodegeneration
(Neural Loss)"]
    
    JUN -->|"regulates"| PKC
    MTORC2 -->|"activates"| PKC
    
    PKC -->|"activates"| NRF2
    PKC -->|"activates"| KEAP1
    PKC -->|"activates"| TNF
    PKC -->|"activates"| AKT
    PKC -->|"activates"| MAPK
    PKC -->|"activates"| PI3K
    PKC -->|"activates"| Apoptosis
    
    TNF -->|"promotes"| Inflammation
    
    PKC -->|"therapeutic target"| ALS
    PKC -->|"inhibits"| MS
    PKC -->|"associated with"| Ataxia
    PKC -->|"associated with"| Neurodegeneration
    
    Inflammation -->|"contributes to"| Neurodegeneration
    Apoptosis -->|"leads to"| Neurodegeneration
    
    style PKC fill:#006494
    style NRF2 fill:#1b5e20
    style AKT fill:#1b5e20
    style JUN fill:#4a1a6b
    style MTORC2 fill:#4a1a6b
    style TNF fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Ataxia fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (360)

Target	Relation	Type	Str
Als	activates	disease	0.95
Als	regulates	disease	0.95
claudin-5	activates	protein	0.90
PI3K	activates	gene	0.90
AKT	activates	gene	0.90
Mapk	activates	pathway	0.90
AMPK	interacts_with	protein	0.85
NRF2	phosphorylates	protein	0.85
calcium signaling	participates_in	pathway	0.85
Alzheimer	therapeutic_target	disease	0.85
Cancer	regulates	disease	0.85
Cancer	activates	disease	0.85
CANCER	activates	gene	0.80
ERK	activates	gene	0.80
Dementia	therapeutic_target	disease	0.75
CANCER	regulates	gene	0.70
RAS	activates	gene	0.70
Nf-Κb	contributes_to	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
GENES	activates	gene	0.70
Nf-Κb	activates	pathway	0.70
BCL-2	activates	gene	0.70
ALX/FPR2 G-protein uncoupling	causes	mechanism	0.70
Apoptosis	regulates	pathway	0.70
GBM microtube network	regulates	process	0.70
oxidative stress response	participates_in	pathway	0.70
ALZHEIMER	therapeutic_target	gene	0.70
MTORC1	regulates	gene	0.70
OVERVIEW	regulates	gene	0.70
DEMENTIA	therapeutic_target	gene	0.70
M1 and nAChR convergent signaling	regulates	mechanism	0.70
Macular Degeneration	regulates	disease	0.65
Breast Cancer	activates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Aging	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Spinocerebellar Ataxia	causes	disease	0.65
Anxiety	activates	disease	0.65
Depression	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Stroke	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Senescence	activates	disease	0.65
Leukemia	activates	disease	0.65

Incoming (169)

Source	Relation	Type	Str
MTORC2	phosphorylates	protein	0.90
JUN	regulates	protein	0.80
EIF2B3	participates_in	gene	0.80
MTORC2	activates	protein	0.72
PI3K	associated_with	gene	0.70
TAU	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
AQP4	activates	gene	0.65
CREB	activates	gene	0.65
PI3K	activates	gene	0.60
NRF2	activates	gene	0.60
FYN	activates	gene	0.60
KEAP1	activates	gene	0.60
BACH1	activates	gene	0.60
MTOR	associated_with	gene	0.60
RB1	inhibits	gene	0.60
AKT	activates	gene	0.60
AKT	regulates	gene	0.60
BACH1	regulates	gene	0.60
CUL3	regulates	gene	0.60
GFAP	activates	gene	0.60
NGF	activates	gene	0.60
P38	regulates	gene	0.60
FOS	regulates	gene	0.60
TNF	expressed_in	gene	0.60
JUN	activates	gene	0.60
FOS	activates	gene	0.60
NRF1	activates	gene	0.60
VEGF	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
NQO1	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
SIRT1	contributes_to	gene	0.60
BDNF	therapeutic_target	gene	0.60
STAT6	therapeutic_target	gene	0.60
BNIP3	activates	gene	0.60
MMP9	activates	gene	0.60
MMP1	activates	gene	0.60
TFEB	regulates	gene	0.60
TLR3	contributes_to	gene	0.60
BDNF	contributes_to	gene	0.60
TRKB	contributes_to	gene	0.60
FGF2	contributes_to	gene	0.60
CGAS	activates	gene	0.60
JNK	activates	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
ALOX5	interacts_with	gene	0.60
HO1	therapeutic_target	gene	0.60
NRF2	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PKC in their description or question text

No additional research found

PKC

Understanding Entity Pages

Summary

Wiki Pages (3)

PRKCA Gene

Protein Kinase C (PKC) Signaling in Parkinson's Disease

PRKCG Protein (PKCγ)

Pathway Diagram

Outgoing (360)

Incoming (169)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

What is the optimal BBB opening duration and spatial precision to maximize thera

Do stellate neurons express unique α7 nicotinic receptor subtypes that could ena

Experiments (0)

Related Papers (0)

Debates (4)

The debate proposed α7-containing heteromers (α7β2) might be enriched in stellat

The debate highlighted receptor desensitization as a critical concern for SPM re

The debate highlighted focused ultrasound as most feasible but didn't resolve cr

The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes

Related Research