Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPHA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EPHA3 (Eph Receptor A3) - a receptor tyrosine kinase involved in neuronal migration, axon guidance, and brain development
| Gene Symbol | EPHA3 |
| Full Name | Eph Receptor A3 |
| Chromosome | 3p11.2 |
| Protein Type | Receptor |
| Function | is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. |
| Primary Expression | the developing brain, with particularly high levels in the ventricular zone, where neural progenitor cells are generated |
| Amino Acids | 982 aa |
| UniProt ID | P29320 |
| NCBI Gene ID | 1972 |
| Ensembl ID | ENSG00000156172 |
| OMIM | 602335 |
| GeneCards | EPHA3 |
| Human Protein Atlas | EPHA3 |
| Associated Diseases | Brain development disorders, Alzheimer's disease |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EPHA3["EPHA3"]
neurodegeneration["neurodegeneration"]
EPHA3 -->|"implicated_in"| neurodegeneration
style EPHA3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity