entity

EPS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

10Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

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Wiki Pages (1)

Knowledge base pages for this entity

Separin (SEPSECS) Protein

protein · 1848 words

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Outgoing (6)

Target	Relation	Type	Str
ALDRED	inhibits	protein	0.72
KEAP1	interacts_with	protein	0.72
NRF2	activates	protein	0.72
OXSTRESS	inhibits	phenotype	0.64
MITODYS	inhibits	phenotype	0.64
PD	treats	disease	0.64

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Cathepsin-Dependent Tau Clearance	0.767	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.644	neurodegeneration	Why does autophagy inhibition improve ne
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
Limited Calcium Release Without Sufficient Cathepsin Efflux	0.580	neurodegeneration	How does controlled lysosomal membrane p

Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak
Cathepsin D Replacement to Overcome Lysosomal Protease Defic	0.434	proteomics	Quantitative proteomics of the aging syn
Cathepsin-Dependent Processing of Pro-Drug Enzymes	0.400	neurodegeneration	How does controlled lysosomal membrane p
Sepsis-Associated Encephalopathy Prevention via Early BBB St	0.000	-	Blood-brain barrier tight junction disru
Cathepsin D Enhancement for Tau Degradation	0.000	-	Tau propagation mechanisms and therapeut

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Tau, neurodegeneration and Alzheimer's disease. [PMID:21214513]	Unknown	Curr Alzheimer Res	2010
TNF-alpha signaling in glaucomatous neurodegeneration. [PMID:18929124]	Unknown	Prog Brain Res	2008

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPS in their description or question text

Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin

Score: 0.570 · neuroscience · 2026-04-22

## Mechanistic Overview Hsp70-based therapy to prevent lysosomal membrane permeabilization and cathepsin release in AD s

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Score: 0.434 · proteomics · 2026-04-25

Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency

Cathepsin-Dependent Processing of Pro-Drug Enzymes

Score: 0.400 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cathepsin-Dependent Processing of Pro-Drug Enzymes starts from the claim that modulating CTSD, U

Sepsis-Associated Encephalopathy Prevention via Early BBB Stabilization

Score: 0.000 · unknown disease · 2026-04-28

Prophylactic tight junction protein cross-linking combined with complement C5a receptor antagonists to prevent initial B

Cathepsin D Enhancement for Tau Degradation

Score: 0.000 · unknown disease · 2026-04-28

Recombinant pro-cathepsin D enhances pathological protein degradation in lysosomes. Targeted delivery of stabilized cath