gene

KEAP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KEAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1155Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for KEAP1 — Kelch-Like ECH-Associated Protein 1

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🧬 Gene Info

Gene Symbol	KEAP1
Full Name	Kelch-Like ECH-Associated Protein 1
Aliases	Page for KEAP1
Protein Type	Adaptor Protein
Function	High-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge)
Subcellular Localization	</th><td>Cytoplasm, Cytoskeleton</td></tr>
Molecular Weight	70 kDa
Amino Acids	624 aa
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Differentiation
UniProt ID	Q14145
GeneCards	KEAP1
Human Protein Atlas	KEAP1
Associated Diseases	ALS, AUTOPHAGY, Aging, Alzheimer, CCRCC
Known Drugs/Compounds	DOXORUBICIN, EPS, gastrodin, Tocopherol, Succinic Anhydride, Methylglyoxal
Interactions	CUL3, NRF2, ULK1, SQSTM1, NFE2L2, EGF
KG Connections	1152 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KEAP1 — AlphaFold Q14145 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KEAP1["KEAP1"] -->|"Ubiquitinates"| NRF2["NRF2"]
    KEAP1 -->|"Degrades"| NRF2
    KEAP1 -->|"Interacts with"| CUL3["CUL3 E3 Ligase"]
    CUL3 -->|"Forms complex"| KEAP1
    Electrophiles["Electrophilic Agents"] -->|"Inhibit"| KEAP1
    Methylglyoxal["Methylglyoxal"] -->|"Modifies"| KEAP1
    Gastrodin["Gastrodin"] -.Interacts with.-> KEAP1
    SQSTM1["SQSTM1/p62"] -->|"Competes for"| KEAP1
    SQSTM1G427R["SQSTM1 G427R"] -.Impairs.-> KEAP1
    NRF2 -->|"Activates"| ARE["Antioxidant Response Elements"]
    ARE -->|"Induces"| Detox["Detoxification Genes"]
    ARE -->|"Induces"| AntiOx["Antioxidant Genes"]
    KEAP1 -.Implicated in.-> Obesity["Obesity"]

Outgoing (759)

Target	Relation	Type	Str
NRF2	regulates	protein	1.00
NRF2	inhibits	protein	1.00
NRF2	activates	gene	1.00
SQSTM1	activates	gene	1.00
P62	activates	gene	1.00
UBIQUITIN	interacts_with	gene	1.00
Oxidative Stress	regulates	pathway	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Oxidative Stress	activates	pathway	1.00
Tumor	activates	disease	1.00
Ferroptosis	activates	pathway	1.00
Tumor	inhibits	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
GENES	regulates	gene	1.00
GENES	activates	gene	1.00
FERROPTOSIS	activates	gene	1.00
NRF2	associated_with	gene	1.00
P62	interacts_with	gene	1.00
Autophagy	activates	pathway	1.00
Oxidative Stress	inhibits	pathway	1.00
Ferroptosis	inhibits	pathway	1.00
CANCER	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
CUL3	interacts_with	gene	0.99
NFE2L2	interacts_with	protein	0.95
Inflammation	regulates	disease	0.95
Carcinoma	activates	disease	0.95
Als	regulates	disease	0.95
Hepatocellular Carcinoma	activates	disease	0.95
Nrf2	inhibits	entity	0.90
Nrf2-mediated Antioxidant Response	involved_in	pathway	0.90
NFE2L2	activates	gene	0.90
NRF2	interacts_with	protein	0.90
AKT	activates	gene	0.90
UBIQUITIN	activates	gene	0.90
UBIQUITIN	regulates	gene	0.90
Apoptosis	activates	pathway	0.90
AMPK	activates	gene	0.90
Oxidative Stress	associated_with	pathway	0.90
OXIDATIVE STRESS	associated_with	gene	0.90
INFLAMMATION	regulates	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
FERROPTOSIS	inhibits	gene	0.90
Nfe2L2	component_of	pathway	0.85
NRF2	binds	gene	0.85
Inflammation	activates	disease	0.85
Inflammation	inhibits	disease	0.85
Aging	regulates	disease	0.85

Incoming (396)

Source	Relation	Type	Str
ROS	activates	gene	1.00
Epalrestat	binds	drug	0.95
SESN2	regulates	gene	0.95
SQSTM1	interacts_with	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
methylglyoxal	modifies	protein	0.90
gastrodin	interacts_with	drug	0.90
Ric	downregulates	process	0.90
SQSTM1	binds_to	protein	0.90
Succinic Anhydride	binds	compound	0.90
MCL	binds_to	drug	0.90
SQSTM1	mediates	protein	0.90
Autophagy	degrades	process	0.90
AUTOPHAGY	activates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
Macroautophagy	degrades	process	0.88
P62	binds	protein	0.88
electrophilic agents	inhibits	phenotype	0.85
Methylglyoxal	binds	compound	0.85
Itaconate	binds	compound	0.85
Fumarate	binds	compound	0.85
EPALRESTAT	targets	drug	0.85
NRF2	inhibits	protein	0.82
SQSTM1	binds	gene	0.80
itaconate	inhibits	metabolite	0.80
GPX4	inhibits	gene	0.80
APOPTOSIS	activates	gene	0.80
ROS	regulates	gene	0.80
Tocopherol	modulates	compound	0.75
AUTOPHAGY	inhibits	pathway	0.74
NRF2	interacts_with	protein	0.72
EPS	interacts_with	drug	0.72
P62	activates	gene	0.70
NRF2	activates	gene	0.70
PI3K	activates	gene	0.70
PP2A	activates	gene	0.70
P62	inhibits	gene	0.70
PINK1	activates	gene	0.70
BAX	therapeutic_target	gene	0.70
NQO1	activates	gene	0.70
GPX4	activates	gene	0.70
CANCER	activates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
MITOPHAGY	activates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.70
AGING	regulates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
ERK	inhibits	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KEAP1

Understanding Entity Pages

Summary

Wiki Pages (21)

KEAP1 — Kelch-Like ECH-Associated Protein 1

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

oxidative-stress-comparison

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

NACET (N-Acetylcysteine Ethyl Ester)

Curcumin for Neurodegeneration

Transcriptional Regulation in Neurodegeneration

alpha-lipoic-acid-neurodegeneration

Ferroptotic Neurons

Oxidative Stress Response in 4R-Tauopathies

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

Oxidative Stress in Neurodegeneration

WNK1 Kinase in Neurodegeneration

Protein SUMOylation Pathway in Neurodegeneration