gene

ERCC8

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ERCC8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CSA - DNA repair protein essential for transcription-coupled nucleotide excision repair

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🧬 Gene Info

Gene Symbol	ERCC8
Aliases	CSA
Function	encodes a key DNA repair protein essential for transcription-coupled nucleotide excision repair (TC-NER).
Primary Expression	the central nervous system:
Amino Acids	396 aa
Ensembl ID	ENSG00000166167
GeneCards	ERCC8
Human Protein Atlas	ERCC8
ERCC8 (CSA)	The 396-amino acid scaffold protein
ERCC6 (CSB)	ATP-dependent chromatin remodeler
DET1	E3 ubiquitin ligase component
CUL4A	E3 ubiquitin ligase core
RBX1	RING-box protein
DDB1	DNA damage binding protein
WD40 repeats	Form a β-propeller structure for protein-protein interactions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERCC8

gene · 1857 words

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Pathway Diagram

graph TD
    ERCC8["ERCC8"]
    neurodegeneration["neurodegeneration"]
    ERCC8 -->|"implicated_in"| neurodegeneration
    style ERCC8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ERCC8 in their description or question text

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