Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ESCRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Endolysosomal Escape | regulates | process | 0.95 |
| Tau Seed Propagation | inhibits | process | 0.95 |
| Transmembrane Cargo Protein Sorting | regulates | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | part_of | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SNCA Aggregation Hijacks the Endosomal Sorting Complex Requi | 0.690 | neurodegeneration | - |
| Blocking Tau Packaging into Small Extracellular Vesicles via | 0.610 | neuroscience | Trans-synaptic tau spreading and propaga |
| O-GlcNAcylation at T212 competes with phosphorylation to red | 0.380 | alzheimers-disease-and-related-tauopathies | How can ESCRT or SNARE targeting achieve |
| CHMP2B vs. CHMP2A Subunit Targeting Creates a Therapeutic Wi | 0.330 | neurodegeneration | What is the therapeutic window between t |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 5 hypotheses Top: 0.780
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ESCRT in their description or question text
No additional research found