Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Early Alzheimer's Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Amyloid-Beta | involved_in | protein | 0.95 |
| excitation/inhibition imbalance | associated_with | phenotype | 0.90 |
| Mild Cognitive Impairment Due To Alzheimer's Disease | associated_with | disease | 0.90 |
| NDEV p-tau181 | biomarker_for | gene | 0.90 |
| Cholinergic Integrity | biomarker_for | biomarker | 0.85 |
| PV+ interneuron dysfunction | associated_with | process | 0.70 |
| closed-loop hippocampal TFUS | therapeutic_target_for | device | 0.70 |
| TREM2 agonism | therapeutic_target_for | drug | 0.70 |
| sTREM2 | biomarker_for | protein | 0.70 |
| NDEV phospho-tau species | biomarker_for | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop transcranial focused ultrasound targeting EC-II | 0.712 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Optogenetic restoration of SST interneuron-mediated dendriti | 0.380 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Age-related neuroinflammation mimics early Alzheimer's disea | 0.362 | Alzheimer's disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.550
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.801
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.532
neurodegeneration | 2026-04-11 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| Quantitative neuropathology characterization of 84 donors revealed ste | neuropathology | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Late-life GFAP (astrogliosis marker) was significantly associated with | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Integrated multiomics and spatial genomics analysis of 84 human donors | neuropathology | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.86 · 2026-04-28
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.59 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
Hypotheses and analyses mentioning Early Alzheimer's Disease in their description or question text
No additional research found