protein

Amyloid-Beta

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Amyloid-Beta: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1918Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	AMYLOID-BETA
Protein Family	Amyloid precursor protein family
Subcellular Localization	Extracellular, membrane-associated
Molecular Weight	4.3 kDa
Amino Acids	43 aa
Pathways	Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P05067
GeneCards	AMYLOID-BETA
Human Protein Atlas	AMYLOID-BETA
Associated Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Dementia
Known Drugs/Compounds	Bispecific Antibodies, Lecanemab, Donanemab
Interactions	AMYLOID-BETA, BAG3, TAU, BMAL1, ASTROCYTE, ASTROCYTES
KG Connections	322 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Amyloid_Beta["Amyloid-Beta"] -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"biomarker for"| Alzheimer_Disease["Alzheimer Disease"]
    style Alzheimer_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"causes"| Cerebral_Amyloid_Angiopathy["Cerebral Amyloid Angiopathy"]
    style Cerebral_Amyloid_Angiopathy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"associated"| Lipid_Droplet_Formation["Lipid Droplet Formation"]
    style Lipid_Droplet_Formation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"causes"| Neuronal_Toxicity["Neuronal Toxicity"]
    style Neuronal_Toxicity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"causes"| Neuronal_Damage["Neuronal Damage"]
    style Neuronal_Damage fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Amyloid_Beta["Amyloid-Beta"] -->|"causes"| Neuronal_Death["Neuronal Death"]
    style Neuronal_Death fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BACE1["BACE1"] -->|"associated"| Amyloid_Beta["Amyloid-Beta"]
    style BACE1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Crocetin["Crocetin"] -->|"associated"| Amyloid_Beta["Amyloid-Beta"]
    style Crocetin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"binds"| Amyloid_Beta["Amyloid-Beta"]
    style TREM2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Microglia["Microglia"] -->|"degrades"| Amyloid_Beta["Amyloid-Beta"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Monoclonal_Antibodies["Monoclonal Antibodies"] -->|"targets"| Amyloid_Beta["Amyloid-Beta"]
    style Monoclonal_Antibodies fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style Amyloid_Beta fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1123)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	causes	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Pro-Inflammatory Cytokine Release	causes	process	0.95
Alzheimer'S Disease	implicated_in	disease	0.95
Early Alzheimer'S Disease	involved_in	disease	0.95
Protein Aggregation	involved_in	process	0.90
Neuronal Function	inhibits	process	0.88
Alzheimer'S Disease Pathology	associated_with	process	0.88
Senile Plaques	contributes_to	phenotype	0.88
Alzheimer's Disease	associated_with	disease	0.85
Tau Pathology	promotes	mechanism	0.85
Synapse Loss	causes	phenotype	0.85
Detergent Extraction Resistance	associated_with	phenotype	0.80
Aging	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	protects_against	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Alzheimer	protects_against	disease	0.60
Als	protects_against	disease	0.60
Tauopathy	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Diabetes	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Alzheimer	activates	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Aging	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Alzheimer	contributes_to	disease	0.60
Alzheimer	degrades	disease	0.60
Als	transports	disease	0.60
Migraine	activates	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Als	activates	disease	0.60
Aging	degrades	disease	0.60
Neurodegeneration	degrades	disease	0.60
Als	degrades	disease	0.60
Dementia	associated_with	disease	0.60

Incoming (795)

Source	Relation	Type	Str
APP	substrate_of	protein	0.95
Hearing Loss	causes	phenotype	0.92
Bispecific Antibodies	targets	drug	0.90
Protein Aggregation	involved_in	process	0.90
PGC1A	downregulates	gene	0.90
Hearing Loss	upregulates	phenotype	0.90
Lecanemab	targets	drug	0.90
Donanemab	targets	drug	0.90
PPARGC1A	downregulates	gene	0.90
TAU	interacts_with	protein	0.90
mTOR Pathway	regulates	pathway	0.80
APOE	regulates	gene	0.80
TFR1	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
APOE	expressed_in	gene	0.60
AGING	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
BAG3	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
TAU	activates	gene	0.60
BMAL1	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
CLOCK	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID-BETA	associated_with	gene	0.60
IL-10	activates	gene	0.60
BDNF	activates	gene	0.60
IGF1R	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
EXERCISE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-1	activates	gene	0.60
APOE	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
PDGFRB	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
TAU	associated_with	gene	0.60
FGF2	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
NPTX1	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
CHIT1	biomarker_for	gene	0.60
IL4	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-12 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Amyloid-Beta

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Mitochondrial Quality Control

Pathway Diagram

Outgoing (1123)

Incoming (795)

Targeting Hypotheses (0)

Mentioning Analyses (6)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Extracellular vesicle biomarkers for early AD detection

Extracellular vesicle biomarkers for early AD detection

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (0)