Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FBXO38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | FBXO38 |
| Chromosome | 5q32 |
| Function | encodes an F-box protein that functions as a critical substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex. |
| Subcellular Localization | the nucleus where it regulates transcription factor degradation |
| Molecular Weight | 80 kDa |
| Amino Acids | 714 aa |
| Exons | 11 |
| Pathways | NF-κB signaling, NF-κB |
| Ensembl ID | ENSG00000170852 |
| GeneCards | FBXO38 |
| Human Protein Atlas | FBXO38 |
| α-helical bundle | Three α-helices that create the SKP1 binding interface |
| Conserved F-box motif | The sequence LXXXLLXXN, critical for SKP1 interaction |
| Linker region | Connects F-box to the substrate recognition domain |
| LRR repeats | Typically 20-30 amino acid motifs with conserved residues |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FBXO38["FBXO38"]
neurodegeneration["neurodegeneration"]
FBXO38 -->|"implicated_in"| neurodegeneration
style FBXO38 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FBXO38 in their description or question text
No additional research found