gene

FGD1

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This page aggregates everything SciDEX knows about FGD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

FGD1 — FYVE, RhoGEF and PH Domain Containing 1

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🧬 Gene Info

Gene Symbol	FGD1
Full Name	FYVE, RhoGEF and PH Domain Containing 1
Function	Unlike broader-spectrum RhoGEFs, FGD1 demonstrates specificity for CDC42 over Rac1 and RhoA [1].
Primary Expression	both excitatory and inhibitory neurons, with highest expression in regions involved in learning and memory
Subcellular Localization	specific cellular compartments and activate CDC42 in response to upstream signals [1]
Ensembl ID	ENSG00000102349
GeneCards	FGD1
Human Protein Atlas	FGD1
PAK (p21-activated kinases)	Serine/threonine kinases that regulate cytoskeletal remodeling
WASP (Wiskott-Aldrich syndrome protein)	Promotes actin polymerization via the Arp2/3 complex
Axonal growth and guidance	CDC42-mediated actin dynamics drive growth cone formation and steering [2]
Dendritic arborization	FGD1 regulates the formation and maintenance of dendritic branches
Dendritic spine formation	The protein is essential for spine morphogenesis and synaptic contact formation [2]
Synaptogenesis	FGD1-CDC42 signaling contributes to presynaptic and postsynaptic development
Brain	Cerebral cortex, hippocampus, cerebellum
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

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Canonical Page

FGD1 — FYVE, RhoGEF and PH Domain Containing 1

gene · 1224 words

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Pathway Diagram

graph TD
    FGD1["FGD1"]
    neurodegeneration["neurodegeneration"]
    FGD1 -->|"implicated_in"| neurodegeneration
    style FGD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Experiments (0)

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Related Research

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