| Gene Symbol | FGD1 |
| Full Name | FYVE, RhoGEF and PH Domain Containing 1 |
| Function | Unlike broader-spectrum RhoGEFs, FGD1 demonstrates specificity for CDC42 over Rac1 and RhoA [1]. |
| Primary Expression | both excitatory and inhibitory neurons, with highest expression in regions involved in learning and memory |
| Subcellular Localization | specific cellular compartments and activate CDC42 in response to upstream signals [1] |
| Ensembl ID | ENSG00000102349 |
| GeneCards | FGD1 |
| Human Protein Atlas | FGD1 |
| PAK (p21-activated kinases) | Serine/threonine kinases that regulate cytoskeletal remodeling |
| WASP (Wiskott-Aldrich syndrome protein) | Promotes actin polymerization via the Arp2/3 complex |
| Axonal growth and guidance | CDC42-mediated actin dynamics drive growth cone formation and steering [2] |
| Dendritic arborization | FGD1 regulates the formation and maintenance of dendritic branches |
| Dendritic spine formation | The protein is essential for spine morphogenesis and synaptic contact formation [2] |
| Synaptogenesis | FGD1-CDC42 signaling contributes to presynaptic and postsynaptic development |
| Brain | Cerebral cortex, hippocampus, cerebellum |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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