Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FZD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Page for FZD8 Gene - Frizzled Class Receptor 8 involved in Wnt signaling and neurodegeneration
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| Gene Symbol | FZD8 |
| Full Name | Frizzled Class Receptor 8 |
| Aliases | Page for FZD8 Gene |
| Chromosome | 10p11.21 |
| Protein Family | Class Frizzled GPCR (7-TM receptor) |
| Function | is a member of the Frizzled family of seven-transmembrane G protein-coupled receptors that function as primary receptors for Wnt ligands. |
| Molecular Weight | 75 kDa |
| Amino Acids | 694 aa |
| Exons | 10 |
| Pathways | Wnt, Wnt pathway, Wnt signaling |
| UniProt ID | Q9H6Y5 |
| NCBI Gene ID | 8325 |
| Ensembl ID | ENSG00000177283 |
| OMIM | 605467 |
| GeneCards | FZD8 |
| Human Protein Atlas | FZD8 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FZD8["FZD8"]
neurodegeneration["neurodegeneration"]
FZD8 -->|"implicated_in"| neurodegeneration
style FZD8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FZD8 in their description or question text
No additional research found