gene

GAAP

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GAAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GAAP Gene - Golgi Anti-Apoptotic Protein

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🧬 Gene Info

Gene Symbol	GAAP
Chromosome	15q25.1
Protein Type	Channel
Function	encodes a multifunctional membrane protein localized primarily to the Golgi apparatus and mitochondria.
Primary Expression	neurons and glia, where it helps maintain calcium homeostasis and protects against various forms of cellular stress that contribute to neurodegenerati
Subcellular Localization	Golgi, mitochondria
Molecular Weight	~38 kDa
Amino Acids	347 aa
Exons	15
Ensembl ID	ENSG00000149691
GeneCards	GAAP
Human Protein Atlas	GAAP
Transmembrane domains	Six predicted transmembrane helices
Calcium channel pore	Formed by transmembrane helices
Golgi targeting signal	C-terminal retention signal
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GAAP Gene - Golgi Anti-Apoptotic Protein

gene · 1913 words

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Pathway Diagram

graph TD
    GAAP["GAAP"]
    neurodegeneration["neurodegeneration"]
    GAAP -->|"implicated_in"| neurodegeneration
    style GAAP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GAAP in their description or question text

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