Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABBR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GABBR1 |
| Full Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 1 |
| Chromosome | 6p21.31 |
| Function | encodes the GABA-B1 subunit of the metabotropic GABA receptor |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum, Thalamus, Basal ganglia |
| Amino Acids | 960 aa |
| UniProt ID | Q9UBS5 |
| NCBI Gene ID | 2550 |
| Ensembl ID | ENSG00000204681 |
| OMIM | 603540 |
| GeneCards | GABBR1 |
| Human Protein Atlas | GABBR1 |
| Ligand recognition | The N-terminal venus flytrap domain (VFT) binds GABA and pharmacological agonists (baclofen) with high affinity |
| Receptor assembly | The coiled-coil domain at the C-terminus mediates obligate heterodimerization with GABBR2 |
| Synaptic localization | Contains an ER retention signal (RSRR) that is masked upon GABBR2 binding, enabling surface trafficking |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GABBR1["GABBR1"]
style GABBR1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
NEURON["NEURON"]
neurodegeneration["neurodegeneration"]
NEURON -.->|"inhibits"| GABBR1
GABBR1 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class NEURON gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURON | inhibits | cell_type | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GABBR1 in their description or question text
No additional research found