Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GBA1 Mutations: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Reduced Glucocerebrosidase Activity | causes | phenotype | 0.90 |
| Parkinson's disease | risk_factor_for | disease | 0.90 |
| PD | increases_risk | disease | 0.90 |
| Symptom Severity Progression | correlates_with | phenotype | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl | 0.700 | neurodegeneration | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-28 | 17 hypotheses Top: 0.828
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GBA1 Mutations in their description or question text
No additional research found