Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GEMIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GEMIN1 |
| Aliases | GEMIN1 gene in ALS and SMA |
| Chromosome | 6q21 |
| Function | encodes a protein of approximately 282 kDa that serves as a molecular scaffold within the SMN complex. |
| Subcellular Localization | </strong> Nucleus (Cajal bodies), cytoplasm</div> <div class="infobox-row"><st |
| Molecular Weight | 282 kDa |
| Ensembl ID | ENSG00000162992 |
| GeneCards | GEMIN1 |
| Human Protein Atlas | GEMIN1 |
| N-terminal Domain | Contains the binding site for the SMN protein, enabling formation of the core SMN-GEMIN1 heterodimer |
| Central Region | Houses the GEMIN1-specific domain that distinguishes this protein from other SMN complex components |
| C-terminal Region | Contains multiple WD40 repeat motifs that mediate protein-protein interactions with other SMN complex members and with snRNA/Sm proteins |
| Cytoplasmic Phase | Initial assembly of the SMN complex occurs in the cytoplasm where it interacts with newly transcribed snRNA and importin-mediated transport |
| Nuclear Phase | The complex localizes to Cajal bodies (also called gemini of coiled bodies), which are nuclear organelles involved in snRNP maturation and recycling |
| mRNA Transport | SMN-GEMIN complexes are involved in the transport of specific mRNAs from the nucleus to the cytoplasm |
| Associated Diseases | ALS |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GEMIN1["GEMIN1"]
neurodegeneration["neurodegeneration"]
GEMIN1 -->|"implicated_in"| neurodegeneration
style GEMIN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GEMIN1 in their description or question text
No additional research found