protein 1,429 words KG: GEMIN1PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:publishedtopic:alstopic:sma
Contents

Gemin-1 Protein (GEMIN1)

🔬 Protein Info
Gene SymbolGEMIN1
AliasesGEMIN1 gene in ALS and SMA
Chromosome6q21
Functionencodes a protein of approximately 282 kDa that serves as a molecular scaffold within the SMN complex.
Subcellular Localization</strong> Nucleus (Cajal bodies), cytoplasm</div> <div class="infobox-row"><st
Molecular Weight282 kDa
Ensembl IDENSG00000162992
GeneCardsGEMIN1
Human Protein AtlasGEMIN1
SMN-Gemin1 InterfaceA hydrophobic interaction surface where SMN binds to the N-terminal domain of Gemin-1
Sm Protein Binding PocketThe WD40 domain contains a binding groove for the Sm proteins
Dimerization InterfaceGemin-1 can form homodimers through its coiled-coil regions
Associated DiseasesALS
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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