gene

GFRA3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GFRA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	GFRA3
Chromosome	5q31.1
Protein Type	Receptor
Function	is a GPI-anchored cell surface receptor that serves as the primary receptor for artemin (ARTN), a member of the glial cell line-derived neurotrophic factor (GDNF) family.
Primary Expression	peripheral nervous system tissues, with lower expression in some brain regions
Molecular Weight	52 kDa
Amino Acids	465 aa
Pathways	PI3K, MAPK
UniProt ID	Q9Y5R5
NCBI Gene ID	63954
OMIM	605331
GeneCards	GFRA3
Human Protein Atlas	GFRA3
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GFRA3 — AlphaFold Q9Y5R5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gfra3

gene · 1064 words

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Pathway Diagram

graph TD
    GFRA3["GFRA3"]
    neurodegeneration["neurodegeneration"]
    GFRA3 -->|"implicated_in"| neurodegeneration
    style GFRA3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFRA3 in their description or question text

No additional research found