protein

GIRK2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GIRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GIRK2/Kir2.2 — G Protein-Activated Inward Rectifier Potassium Channel 2

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🔬 Protein Info

Gene Symbol	GIRK2
Full Name	GIRK2 (G Protein-Activated Inward Rectifier Potassium Channel 2)
Aliases	G Protein-Activated Inward Rectifier Potassium Channel 2
Protein Family	Inward rectifier potassium channel (Kir2.x)
Protein Type	Channel
Function	GIRK2 channels serve critical physiological roles
Primary Expression	dopaminergic neurons of the substantia nigra pars compacta (SNpc)
Subcellular Localization	Plasma membrane, , axon terminals
Molecular Weight	~50 kDa
UniProt ID	P48051
GeneCards	GIRK2
Human Protein Atlas	GIRK2
Four transmembrane domains	M1 and M2 helices form the channel pore
Selectivity filter	GYG motif confers K+ selective permeation
Cytoplasmic domains	N-terminus and C-terminus interact with G-protein beta-gamma subunits
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GIRK2 — AlphaFold P48051 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GIRK2/Kir2.2 — G Protein-Activated Inward Rectifier Potassium Channel 2

protein · 1016 words

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Pathway Diagram

graph TD
    GIRK2["GIRK2"]
    neurodegeneration["neurodegeneration"]
    GIRK2 -->|"implicated_in"| neurodegeneration
    style GIRK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GIRK2 in their description or question text

No additional research found