Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GJC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GJC2 |
| Chromosome | 6q22.31. |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | peripheral myelinating glia - CNS white matter: Highest expression in corpus callosum, internal capsule - Timing: Expression increases during |
| Molecular Weight | 42.8 kDa |
| Amino Acids | 440 aa |
| Ensembl ID | ENSG00000146070 |
| GeneCards | GJC2 |
| Human Protein Atlas | GJC2 |
| Oligodendrocytes | High expression in myelinating oligodendrocytes |
| [Astrocytes](/entities/astrocytes) | Moderate expression, especially in white matter astrocytes |
| Schwann cells | Expressed in peripheral myelinating glia |
| CNS white matter | Highest expression in corpus callosum, internal capsule |
| Timing | Expression increases during active myelination periods |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GJC2["GJC2"]
neurodegeneration["neurodegeneration"]
GJC2 -->|"implicated_in"| neurodegeneration
style GJC2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GJC2 in their description or question text
No additional research found