Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GLI3 |
| Full Name | GLI Family Zinc Finger 3 |
| Chromosome | 7p14.1 |
| Protein Type | Transcription Factor |
| Function | encodes a 1580 amino acid zinc finger transcription factor that functions as the principal transcriptional repressor of the Hedgehog (Hh) signaling pathway. |
| Primary Expression | dorsal and intermediate regions of the neural tube, where its repressor form (GLI3R) restricts ventral cell fates |
| Molecular Weight | 83 kDa |
| Amino Acids | 1580 aa |
| Exons | 15 |
| Ensembl ID | ENSG00000106571 |
| GeneCards | GLI3 |
| Human Protein Atlas | GLI3 |
| Acrocallosal Syndrome (ACLS) | Overlaps with GCPS; features corpus callosum agenesis and intellectual disability. |
| Proteasome inhibitors | Block GLI3 processing to GLI3R; research tool for studying GLI3A-dependent transcription |
| PKA inhibitors | Prevent initiating phosphorylation required for GLI3 processing |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GLI3["GLI3"]
neurodegeneration["neurodegeneration"]
GLI3 -->|"implicated_in"| neurodegeneration
style GLI3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GLI3 in their description or question text
No additional research found