Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLRBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLRB (Glycine Receptor Beta) is the beta subunit of the glycine receptor, a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system.
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| Gene Symbol | GLRBPROTEIN |
| Protein Type | Channel |
| Function | is a pentameric ion channel belonging to the Cys-loop receptor superfamily, which also includes GABA_A receptors and nicotinic acetylcholine receptors. |
| Primary Expression | the spinal cord and brainstem, where it participates in motor control, sensory processing, and reflex modulation |
| Molecular Weight | 55 kDa |
| Amino Acids | 495 aa |
| GeneCards | GLRBPROTEIN |
| Human Protein Atlas | GLRBPROTEIN |
| TM1 (221-244 amino acids) | Lines the channel pore and participates in gating |
| TM2 (245-266 amino acids) | Forms the ion channel pore; key residues determine chloride selectivity |
| TM3 (280-315 amino acids) | Contributes to the channel wall and allosteric coupling |
| TM4 (340-365 amino acids) | Forms the outermost helix and interacts with lipid environment |
| Motor control and coordination | Inhibitory interneurons modulate motor neuron activity |
| Sensory processing | Glycine receptor function in dorsal horn neurons modulates pain and touch sensations |
| Reflex arcs | Rapid inhibitory responses in spinal reflex pathways |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GLRBPROTEIN["GLRBPROTEIN"]
neurodegeneration["neurodegeneration"]
GLRBPROTEIN -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning GLRBPROTEIN in their description or question text
No additional research found