protein

GLUR6PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GLUR6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GLUR6PROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the hippocampus, cerebral cortex, and cerebellum, where they play important roles in synaptic t
Amino Acids	400 aa
GeneCards	GLUR6PROTEIN
Human Protein Atlas	GLUR6PROTEIN
Transmembrane domain (TMD)	Three transmembrane helices (M1, M3, M4) and a reentrant pore loop (M2) form the ion channel. The M2 pore loop determines ion selectivity and conductance properties.
Higher Ca2+ permeability	Unlike Q/R-edited AMPA receptors, GluR6 shows significant Ca2+ influx through the channel pore
Distinct pharmacological profile	Unique agonist and antagonist sensitivity compared to other kainate subunits
Multiple splice variants	Alternative splicing generates isoforms with distinct C-terminal tails and properties
Q/R RNA editing	The Q/R site is partially edited in humans (~60-80% depending on brain region), reducing Ca2+ permeability
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GluR6 Protein

protein · 1024 words

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Pathway Diagram

graph TD
    GLUR6PROTEIN["GLUR6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GLUR6PROTEIN -->|"implicated_in"| neurodegeneration
    style GLUR6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning GLUR6PROTEIN in their description or question text

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