protein

GLUR7PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GLUR7PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GLUR7PROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	to extrasynaptic sites ### Presynaptic Modulation GluR7 is predominantly found
GeneCards	GLUR7PROTEIN
Human Protein Atlas	GLUR7PROTEIN
Ligand-binding domain (LBD)	The S1S2 domain shows high-affinity glutamate binding with unique conformational properties that distinguish it from other GRIK subunits<sup>[1]</sup>
Transmembrane region	Four transmembrane helices (M1-M4) forming the ion channel pore
C-terminal tail	Contains a PDZ-binding motif (X-S/T-X-Φ) that enables interactions with synaptic scaffolding proteins
N-terminal domain	Contributes to receptor assembly and subunit specificity
GluR7a	Full-length variant widely expressed in the brain
GluR7b	Alternative C-terminus with altered trafficking properties
GluR7c	Variant with altered desensitization kinetics
High-affinity glutamate binding	Kd in the nanomolar range, similar to GluR8
Partial agonist responses	Shows partial agonist activity for certain compounds
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GluR7 Protein

protein · 999 words

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Pathway Diagram

graph TD
    GLUR7PROTEIN["GLUR7PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GLUR7PROTEIN -->|"implicated_in"| neurodegeneration
    style GLUR7PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

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