protein

GLUR8PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GLUR8PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GLUR8PROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	specific brain regions, playing important roles in synaptic transmission and circuit function
GeneCards	GLUR8PROTEIN
Human Protein Atlas	GLUR8PROTEIN
High-affinity glutamate binding domain	The ligand-binding domain (LBD) of GluR8 shows the highest affinity for glutamate among all kainate receptor subunits, with Kd values in the sub-micromolar range<sup>[1]</sup>
Distinct binding pocket	The ligand-binding pocket has unique amino acid residues that confer selective pharmacology compared to other GRIK subunits<sup>[1]</sup>
Transmembrane domain	Four transmembrane segments (M1-M4) that form the ion channel pore
C-terminal tail	Intracellular domain involved interactions and trafficking
Highest kainate affinity	GRIK4-containing receptors in protein bind kainate with the highest affinity among all kainate receptor configurations
LY382884 sensitivity	Particularly sensitive to the selective antagonist LY382884
ATPA agonist	Responds uniquely to (2S,4R)-4-Phosphonomethyl-2-pyrrolidineacetic acid (ATPA), a GluR5-selective agonist
Concanavalin A modulation	Uniquely modulated by concanavalin A in some splice variants
GluR8a	Full-length variant with highest expression in the hippocampus
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GluR8 Protein

protein · 1085 words

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Pathway Diagram

graph TD
    GLUR8PROTEIN["GLUR8PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GLUR8PROTEIN -->|"implicated_in"| neurodegeneration
    style GLUR8PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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