gene

GPR161

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GPR161: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

Comprehensive information about GPR161, a negative regulator of Hedgehog signaling implicated in neural tube development, medulloblastoma, and potential roles in adult neurogenesis and neurodegenerative disease.

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🧬 Gene Info

Gene Symbol	GPR161
Full Name	G Protein-Coupled Receptor 161
Chromosome	1q24.2
Function	is a GPCR involved in Hedgehog signaling and neural tube development.
Molecular Weight	77 kDa
Amino Acids	713 aa
Exons	12
UniProt ID	Q9Y4X5
NCBI Gene ID	266977
Ensembl ID	ENSG00000135547
GeneCards	GPR161
Human Protein Atlas	GPR161
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GPR161 — AlphaFold Q9Y4X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GPR161 — G Protein-Coupled Receptor 161

gene · 2976 words

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Pathway Diagram

graph TD
    GPR161["GPR161"]
    neurodegeneration["neurodegeneration"]
    GPR161 -->|"implicated_in"| neurodegeneration
    style GPR161 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GPR161 in their description or question text

No additional research found